Expression of muscle genes related to magnesium transport and homeostasis in response to Mg status in mice (doi:10.15454/IVBODD)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
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Document Description

Citation

Title:

Expression of muscle genes related to magnesium transport and homeostasis in response to Mg status in mice

Identification Number:

doi:10.15454/IVBODD

Distributor:

Portail Data INRAE

Date of Distribution:

2021-06-24

Version:

1

Bibliographic Citation:

Bechet, Daniel, 2021, "Expression of muscle genes related to magnesium transport and homeostasis in response to Mg status in mice", https://doi.org/10.15454/IVBODD, Portail Data INRAE, V1, UNF:6:th/cxzuWD8YN9ODYHQHWAg== [fileUNF]

Study Description

Citation

Title:

Expression of muscle genes related to magnesium transport and homeostasis in response to Mg status in mice

Identification Number:

doi:10.15454/IVBODD

Authoring Entity:

Bechet, Daniel (INRA - Institut National de la Recherche Agronomique)

Distributor:

Portail Data INRAE

Access Authority:

Bechet, Daniel

Depositor:

Bechet, Daniel

Date of Deposit:

2021-04-11

Study Scope

Keywords:

Human Nutrition and food security

Abstract:

Chronic Mg2+ deficiency is at the origin of a broad range of health dysfunctions. Because 25% of body Mg2+ is located in the skeletal muscle, Mg2+ transport and homeostasis systems (MgTHs) in muscle are critical for whole body Mg2+ homeostasis. In the present study, we assessed whether Mg2+ deficiency alters muscle fiber characteristics and major pathways regulating muscle physiology. C57BL/6J mice were fed for 14 days either a control, mildly or severely Mg2+-deficient diet (0.1%; 0.01%; and 0.003% Mg2+ wt/wt, respectively). Mg2+ deficiency slightly decreased body weight gain, muscle Mg2+ concentrations, but was not associated with detectable variations in gastrocnemius muscle weight, fiber morphometry and capillarization. Nonetheless, to maintain Mg2+ homeostasis muscles exhibited decreased expression of several MgTHs (Magt1, Cnnm2, Cnnm4 and Trpm6). MgTHs mRNA levels were positively correlated with body weight gain. Moreover, TaqMan Low Density Array (TLDA) analyses further revealed that, before the emergence of major muscle dysfunctions, even a mild Mg2+ deficiency was sufficient to alter expression of genes critical for muscle physiology, including energy metabolism, muscle regeneration, proteostasis, mitochondrial dynamics and excitation-contraction coupling.

Kind of Data:

Dataset

Methodology and Processing

Sources Statement

Data Access

Notes:

<img src="https://www.etalab.gouv.fr/wp-content/uploads/2011/10/licence-ouverte-open-licence.gif" alt="Licence Ouverte" height="100"><a href="https://www.etalab.gouv.fr/licence-ouverte-open-licence">Licence Ouverte / Open Licence Version 2.0</a> compatible CC BY

Other Study Description Materials

File Description--f109740

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  • Type of File: text/tab-separated-values

Notes:

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Variable Description

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Variables

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